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Drugs Effective in the Therapy of the Epilepsies


Drugs Effective in the Therapy of the Epilepsies Overview The epilepsies are common and frequently devastating disorders, affecting approximately 2.5 million people in the United States alone. More than 40 distinct forms of ep
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Neurotransmission: The Autonomic and Somatic Motor Nervous Systems


Neurotransmission: The Autonomic and Somatic Motor Nervous Systems Overview The theory of neurohumoral transmission received direct experimental validation nearly a century ago (see von Euler, 1981), and extensive investigatio
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Treatment of Mania

Treatment of Mania Antimanic Mood-Stabilizing Agents: Lithium Lithium carbonate was introduced into psychiatry in 1949 for the treatment of mania (Cade, 1949; seeMitchell et al., 1999). However, it was not used for this purpose
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Antihypertensive Agents and the Drug Therapy of Hypertension

Antihypertensive Agents and the Drug Therapy of Hypertension Overview Arterial pressure is the product of cardiac output and peripheral vascular resistance. Drugs lower pressure by actions on either the peripheral resistance o
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NBME STEP 1 PATHOLOGY


NBME STEP 1 PATHOLOGY INFLAMMATION 1.         A 40-year-old man has the recent onset of right-sided chest pain, difficulty breathing, and fever. On auscultation he has crackles, decreased respiratory sounds, and evidence of a right-sided
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Drug Therapy for Hypercholesterolemia and Dyslipidemia

Drug Therapy for Hypercholesterolemia and Dyslipidemia Overview Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions, such as coronary heart disease, ischemic cerebrovascular disease, an
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Antimicrobial Agents: Antifungal Agents

Antimicrobial Agents: Antifungal Agents Overview Fungal infections traditionally have been divided into two distinct classes: systemic and superficial. Consequently, the major antifungal agents described in this chapter are dis
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Gene Therapy


Gene Therapy Overview Advances in molecular and cellular biology have described the proteins that mediate many disease processes, while DNA technology provides ready access to the genes that control these events. The size, c
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Drugs Used in the Chemotherapy of Helminthiasis

Drugs Used in the Chemotherapy of Helminthiasis Overview Helminthiasis, or infection with parasitic worms, affects over two billion people worldwide. In tropical regions, where prevalence is greatest, simultaneous infection wi
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Renin and Angiotensin


Renin and Angiotensin Overview In the early 1970s, pharmacological interruption of the renin–angiotensin system was considered sensible only for patients with high-renin hypertension. In the ensuing years, however, an extrao
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History and Principles of Anesthesiology

History and Principles of Anesthesiology *Overview Prior to 1846, attempts to provide comfort during operative procedures were minimally effective and the development of surgery was necessarily limited. William T.G. Morton
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Principles of Therapeutics


Principles of Therapeutics Overview The regulations governing the development of new drugs have evolved over the past century to assure the safety and efficacy of new medications for the population. The safety or efficacy of a
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Drugs Used in the Chemotherapy of Protozoal Infections: Malaria


Drugs Used in the Chemotherapy of Protozoal Infections: Malaria Overview Malaria, caused by four species of Plasmodium, of which Plasmodium falciparum is the most dangerous, remains the world's most devastating human parasitic
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General Anesthetics

General Anesthetics *Overview General anesthetics are a class of drugs used to depress the central nervous system to a sufficient degree to permit the performance ofsurgery and other noxious or unpleasant procedures. Not
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Chemotherapy of Microbial Diseases

Chemotherapy of Microbial Diseases   Overview Antimicrobial agents, the general classes of these drugs, and their mechanisms of action and mechanisms of bacterial resistance are reviewed in this chapter. The principles
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Anaphylaxis and Allergic Reactions

Anaphylaxis and Allergic Reactions   Anaphylaxis is the most severe form of an allergic reaction, and has the potential to be life-threatening. Anaphylaxis occurs after exposure to an allergen (such as food, latex, insect sting or medicin
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Cervical Dystonia: Description, Symptoms

Cervical Dystonia Description Cervical dystonia or CD, also known as spasmodic torticollis, is a form of focal dystonia. It is also the most common form of focal dystonia. CD is characterized by abnormal movements or postures of the neck and
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VASCULAR ACCESS - Early Diagnosis and Treatment of Complications

VASCULAR ACCESS - Early Diagnosis and Treatment of Complications Co-director of Nephrology and Transplantation and the Medical Director of the Clinical Laboratory, Austin Diagnostic Clinic, Austin, TX Today we are spending about a billion d
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Hepatitis - What is viral hepatitis?


Hepatitis What is viral hepatitis?           Hepatitis means inflammation of the liver. Many illnesses and conditions can cause inflammation of the liver, for example, drugs, alcohol, chemicals, and autoimmune diseases. Many viruses, f
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BARBITURATES INTOXICATION

BARBITURATES INTOXICATION Background: Barbiturates are the earliest known class of sedative-hypnotic agents and were once extremely popular drugs to abuse. Benzodiazepines largely have replaced barbiturates for outpatient medical
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